Clinical Trials

Informed consent forms for interventional oncology clinical trials are often lengthy and written at too high of a reading level for some patients, making it hard for them to weigh the decision to participate, according to study results.

Staffing challenges have contributed to a “crisis” in new clinical research, with 95% of cancer centers reporting personnel issues resulting from the “great resignation,” according to Society for Immunotherapy of Cancer.

Dupilumab had good overall survival for up to 3 years in patients with atopic dermatitis, according to a study.

NEW YORK — There are racial and gender disparities in the enrollment of participants in clinical trials for diabetic macular edema, according to a poster presented at the American Society of Retina Specialists annual meeting.

The NIH has awarded $3.35 million to Oligomerix Inc. for clinical development of its lead program, OLX-07010, an oral tau self-association small molecule inhibitor for the treatment of early-stage Alzheimer’s disease.

SAN DIEGO — In older adult patients with Alzheimer’s-related dementia, treatment with brexpiprazole resulted in greater reduction in agitation compared with placebo, while proving to be safe and well-tolerated.

Karuna Therapeutics Inc. announced positive results from its phase 3 EMERGENT-2 trial evaluating the efficacy, safety and tolerability of its investigational therapy for adults with schizophrenia.

SAN DIEGO — Diagnostic outcomes varied in nearly 40% of a study population when different criteria were used to diagnose Alzheimer’s disease, per a presenter at the Alzheimer’s Association International Conference.

SAN DIEGO — With prevalence of age-related cognitive decline and limited curative treatment options, nutritional interventions may prevent or delay symptom onset, per a presenter at the Alzheimer’s Association International Conference.

Although efforts have been made to increase sharing of individual participant data from clinical trials, data from many oncology clinical trials that support FDA approval of anticancer therapies remain unavailable to researchers.