Cholesterol
Assessment of Lp(a) role in all atherogenic lipoproteins possible with existing assays
Favorable CV health in middle age may lower lifetime risk for type 2 diabetes
Evidence-based statin recommendations underutilized for patients living with HIV
Genetic prediction enables early widespread primary prevention of CAD
CAD has proved to be a highly preventable disease. Reduction in risk for CAD has been accomplished by changes in lifestyle such as cessation of smoking or lowering plasma cholesterol by drug therapy. Multiple randomized placebo-controlled clinical trials since the early 1990s targeting lowering of plasma cholesterol have consistently been associated with a 30% to 40% reduction in cardiac morbidity and mortality. Despite these efforts, CVD remains the most common cause of death in the U.S. and is also the most common cause of death throughout the world. Secondary prevention has been effective, whereas primary prevention offers even greater benefits and is more appropriate, if not necessary, to reduce this pandemic.