Chemoprevention

Low-dose aspirin significantly reduced risk for colorectal cancer recurrence among patients with mutations in the PI3K pathway, according to results of the randomized ALASCCA study presented at ASCO Gastrointestinal Cancers Symposium.

Mass antibiotic administration to children in sub-Saharan Africa reduced mortality rates, but there was little benefit when dosing was limited to infants aged 1 to 11 months, as recommended by WHO, according to results from the AVENIR trial.

Treatment for Helicobacter pylori infection was associated with reduced risk for gastric cancer among patients with a high genetic risk, suggesting that chemoprevention should be personalized to genetic risk, according to data.

A combination of imiquimod 5% cream, 5-fluorouracil 2% solution and tretinoin 0.1% cream may be an effective chemoprevention option for reducing the incidences of keratinocyte carcinomas for at least 1 year, according to a study.

A combination of seasonal vaccination and chemoprevention reduced malaria episodes and deaths among children by around 70% compared with either intervention alone during a 3-year study in two African countries, researchers reported.

The American Gastroenterological Association published a clinical practice update to describe the role of medications for the chemoprevention of colorectal neoplasia.

The U.S. Preventive Services Task Force today recommended that clinicians offer breast cancer risk-reducing medications such as tamoxifen, raloxifene and aromatase inhibitors to asymptomatic women aged 35 years and older who are at elevated risk for developing the disease and low risk for adverse effects from the treatments.