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Checkpoint Inhibitor Therapy

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August 31, 2020
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Checkpoint induced arthritis severely impacts QoL for patients with cancer

Checkpoint induced arthritis severely impacts QoL for patients with cancer

Patients with immune checkpoint therapy-induced inflammatory arthritis report significant social, functional and emotional impacts, compared with cancer and other side effects, according to findings published in BMC Rheumatology.

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July 17, 2020
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Walking the tightrope: Balancing tumor response, adverse events of checkpoint inhibitors

Walking the tightrope: Balancing tumor response, adverse events of checkpoint inhibitors

Time moves in funny ways in medicine. Physicians and researchers can work for decades in obscurity on a cure for a particular disease and make little progress. But once the critical breakthrough comes, 6 months or a year can change everything.

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July 13, 2020
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Early intervention needs to be a ‘team sport’ to curb checkpoint inhibitor-related irAEs

Early intervention needs to be a ‘team sport’ to curb checkpoint inhibitor-related irAEs

Early intervention is critical in managing patients with immune-related adverse events associated with cancer checkpoint inhibitor therapy, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit.

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July 07, 2020
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Immunotherapy shows activity against brain metastases among certain patients with NSCLC

Immunotherapy shows activity against brain metastases among certain patients with NSCLC

Sarah B. Goldberg, MD, MPH, and colleagues conducted a phase 2 study to test the PD-1 inhibitor pembrolizumab among patients with stage IV non-small cell lung cancer and small brain metastases that had not been previously treated or had progressed after radiotherapy.

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June 23, 2020
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Immune checkpoint inhibitors may induce hyperglycemia, worsen insulin resistance for some

Immune checkpoint inhibitors may induce hyperglycemia, worsen insulin resistance for some

A subset of patients with cancer who received an immune checkpoint inhibitor developed new hyperglycemia, suggesting the therapy may play a role in immune-related insulin resistance.

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June 10, 2020
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Balancing tumor response, adverse events remains 'unmet need' for checkpoint inhibitors

Balancing tumor response, adverse events remains 'unmet need' for checkpoint inhibitors

Coordinated care between oncology and rheumatology is one of the key principles of the EULAR recommendations for management of immune-related adverse events associated with cancer checkpoint inhibitor therapy, according to data presented at the EULAR 2020 E-Congress.

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May 04, 2020
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EULAR: Rheumatologist, oncologist collaboration 'pivotal' to enhance checkpoint inhibitor management

EULAR: Rheumatologist, oncologist collaboration 'pivotal' to enhance checkpoint inhibitor management

Oncologists should be encouraged to promptly consult with rheumatologists in the event of suspected immune-related adverse events due to checkpoint inhibitor therapy, according to a series of “points to consider” published by EULAR in the Annals of the Rheumatic Diseases.

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March 11, 2020
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The Rheumatologist, Cancer and the Breakthrough, Part 2

The Rheumatologist, Cancer and the Breakthrough, Part 2

In this episode, Leonard H. Calabrese, DO, is joined by his colleague and daughter Cassandra Calabrese, DO, as they discuss specifics of irAEs, including unusual toxicities, rheumatic conditions associated with checkpoint inhibitors and the rheumatologist’s role in this new area of medicine.

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February 29, 2020
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Despite advances, rheumatic effects of checkpoint therapy poorly defined

Despite advances, rheumatic effects of checkpoint therapy poorly defined

SCOTTSDALE, Arizona — The rheumatic effects of checkpoint therapy remain, despite their increased spotlight in recent years, among the most poorly defined of the immune-related adverse events associated with the emerging cancer treatment, according to Cassandra Calabrese, DO, of the Cleveland Clinic.

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February 26, 2020
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MRI may help differentiate checkpoint inhibitor-induced arthritis, other joint pain

MRI may help differentiate checkpoint inhibitor-induced arthritis, other joint pain

MRI imaging may help physicians distinguish between inflammatory arthritis caused by immune checkpoint inhibitors from other joint pain, and aid in identifying patients who are at an increased risk for joint damage, according to data published in JAMA Network Open.

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