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Cerebrospinal Fluid

Clinical Guidance
Multiple Sclerosis
Presentation and Diagnosis

Critical Diagnostic Criteria

Pavan Bhargava, MD

Free clinical reference tool that includes treatment options; diagnosis information; guidelines; and more.

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May 31, 2024
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Well-regulated sleep vital for functional glymphatic system

Well-regulated sleep vital for functional glymphatic system

DENVER — For the glymphatic system of the brain to function properly, individuals must pay attention to their sleep duration, regulation and deprivation, according to a presenter at the American Academy of Neurology annual meeting.

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April 18, 2024
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Metagenomic sequencing may be valuable for diagnosing infectious disease

Metagenomic sequencing may be valuable for diagnosing infectious disease

DENVER — Metagenomic next-generation sequencing may be a reliable diagnostic tool to analyze causes of highly contagious meningitis or encephalitis in a clinical setting, according to a speaker.

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October 13, 2023
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Fenebrutinib linked to reduced lesion activity, higher CSF penetration in MS at 12 weeks

Fenebrutinib linked to reduced lesion activity, higher CSF penetration in MS at 12 weeks

In relapsing forms of multiple sclerosis, fenebrutinib treatment led to reduction of lesion activity and resulted in higher penetration into cerebrospinal fluid at 12 weeks, according to research from ECTRIMS 2023.

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January 09, 2023
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Quantitative test to measure neurofilament light chain validated

Quantitative test to measure neurofilament light chain validated

Quanterix Corp. announced the validation of a laboratory developed test to quantitatively measure neurofilament light chain in serum as an aid in the evaluation of those who may have neurodegenerative conditions.

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December 12, 2022
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Rhinorrhea treatment reveals cerebrospinal fluid leak

Rhinorrhea treatment reveals cerebrospinal fluid leak

LOUISVILLE, Ky. — Imagine a patient who has been treated for rhinorrhea, but then fluid begins to leak out of their ear. Now imagine that you are a medical student encountering this puzzle on the first day of your allergy elective.

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July 12, 2022
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CSF diversion did not improve outcome in kids after TBI

CSF diversion did not improve outcome in kids after TBI

Cerebrospinal fluid diversion was not associated with improved outcome for children following a traumatic brain injury. However, a decrease in intracranial pressure was observed, researchers reported in JAMA Network Open.

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February 08, 2022
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Detection of amyloid abnormality higher in CSF vs. PET in Alzheimer’s

Detection of amyloid abnormality higher in CSF vs. PET in Alzheimer’s

Evidence of amyloid abnormality across the Alzheimer’s disease spectrum is more prevalent with cerebrospinal fluid testing, according to a cross-sectional, individual-participant pooled study published in JAMA Neurology.

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September 20, 2021
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Traits differ between idiopathic intracranial hypertension diagnosed younger, older

Later idiopathic intracranial hypertension diagnoses occurred less often in women with slightly lower cerebrospinal fluid opening pressure and fewer headaches, according to a retrospective, clinical cohort study.

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July 15, 2021
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CSF conversion assay identifies cognitive impairment due to probable Lewy body disease

CSF conversion assay identifies cognitive impairment due to probable Lewy body disease

A cerebrospinal fluid alpha-synuclein real-time, quaking-induced conversion assay demonstrated efficacy as a “robust biomarker” for identifying mild cognitive impairment due to probable Lewy body disease, according to researchers.

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