Carbapenem-Resistant Enterobacteriaceae

Multidrug-resistant bacteria were believed to spread to rooms in a Japanese pediatric ward through sink drains and plumbing, as replacing contaminated sinks did not end the outbreak, according to a recent study.

After the construction of two ICUs, researchers found that contamination with carbapenem-resistant organisms of the in-room sinks happened quickly.

Although the current approach to incentivizing antibiotic development has led to the creation of effective treatments, the pipeline has collapsed numerous times, leaving clinicians stranded against increasingly resistant infections, according to an article published the Annals of Internal Medicine.

The Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator, or CARB-X, granted Vaxxilon AG up to $1.4 million in nondilutive funding to develop a multivalent vaccine to prevent infections caused by carbapenem-resistant Klebsiella pneumoniae, according to a news release.

Researchers estimated that approximately 23% of carbapenem resistant Enterobacteriaceae, or CRE, infections in the United States are treated with new anti-CRE antibiotics compared with about 28% of infections treated with IV polymyxins.

The antimicrobial market is broken and not everyone agrees on how to fix it.

SAN FRANCISCO — Epidemiologic data and whole genome sequencing revealed a more than 3-year-long transmission of a single bacterial strain with antibiotic-resistant genes in a northern California hospital, according to data presented at ASM Microbe.

ATLANTA — Researchers found that antimicrobial resistance genes were shared among unrelated bacteria during an outbreak of carbapenem-resistant Enterobacteriaceae in a Kentucky hospital, according to findings presented at ASM Microbe.

Carbapenem-resistant Enterobacteriaceae, or CRE, is transmitted within and between a variety of health care settings in Washington, D.C., a study presented at the Society for Healthcare Epidemiology of American spring conference suggests.