Bone Mineral Density

Bone mineral content and density improved following a resistance training program included with school-based physical education for middle school girls, and these results largely held in subsequent years, according to findings presented at the American Society of Bone and Mineral Research annual meeting.

Postmenopausal women who took denosumab for a year did experienced no significant decrease in bone mineral density after switching to alendronate, according to findings presented at the American Society of Bone and Mineral Research annual meeting.

Debate continues among endocrinologists regarding what constitutes the “optimal” level of vitamin D, and dozens of studies have assessed the benefits of vitamin D supplementation on everything from fracture risk to diabetes and autoimmune disease. Most recently, the large-scale VITAL trial, presented in November at the American Heart Association Scientific Sessions, suggested the supplement failed to prevent major cardiovascular events and the development of invasive cancers over 5 years, although a deeper dive into the findings reveals a signal for benefits with vitamin D for certain subsets of patients.

Older women randomly assigned a daily 1.2 g calcium supplement for 5 years were no more likely to develop abdominal aortic calcification vs. similar women assigned placebo, according to study data presented at the American Society for Bone and Mineral Research annual meeting.

Approximately 11% of middle-aged adults in the United States have osteoporosis, with the cost for care rising by nearly $50 billion over more than a decade, according to study data presented at the American Society for Bone and Mineral Research annual meeting.

In a cohort of older adults who lost weight while participating in a lifestyle program, both those who went on to maintain their weight loss and those who regained weight after the program were susceptible to reductions of bone mineral density at the hip, according to findings published in Obesity.

High serum sclerostin levels are independently correlated with low muscle mass in healthy Korean adults, according to findings published in Bone.

Postmenopausal women with osteoporosis who received a regimen of three separate, 6-month cycles of daily teriparatide followed by one subcutaneous injection of denosumab experienced a moderate gain in cortical bone mineral density at 18 months that was not observed among similar women who received the standard regimen of 18 months of teriparatide followed by 18 months of denosumab, according to findings published in the Journal of Bone and Mineral Research.

Postmenopausal, normoglycemic women with a first-degree family history of diabetes have a higher bone mineral density at the lumbar spine and femoral neck when compared with similar women without a family history of the disease, according to findings published in Menopause.

Radius Health has initiated enrollment for a phase 3 clinical trial to assess the safety and efficacy of a wearable abaloparatide-transdermal patch in the treatment of postmenopausal women with osteoporosis at high risk for fracture, the company announced in a press release.