Blood Transfusion
Sex of red blood cell donor has no significant impact on transfusion recipient mortality
The sex of red blood cell donors did not have a significant impact on survival outcomes of transfusion recipients, according to study results published in The New England Journal of Medicine.
Tranexamic acid may reduce blood loss, transfusion rates after hemiarthroplasty, THA
LAS VEGAS — Results showed tranexamic acid may reduce blood loss and transfusion requirements postoperatively among patients who underwent hemiarthroplasty or total hip arthroplasty for pathologic hip fractures.
Researchers identify transfusion threshold that confers lower mortality risk in VV ECMO
Packed red blood cell transfusion improved survival among adults with acute respiratory distress syndrome on venovenous extracorporeal membrane oxygenation when using a hemoglobin threshold of less than 7 g/dL, according to study results.
Imetelstat confers durable transfusion independence in lower-risk myelodysplastic syndrome
Imetelstat conferred a “highly statistically significant and clinically meaningful benefit” vs. placebo in enabling certain patients with myelodysplastic syndrome to achieve transfusion independence, according to the agent’s manufacturer.
Q&A: Maternal SARS-CoV-2 infection, disseminated intravascular coagulation linked
Even in cases of mild or asymptomatic COVID-19, severe disseminated intravascular coagulation was a possibility for pregnant people, findings from a retrospective case series show.
Planned Parenthood closures linked to increased risk for severe maternal morbidity
Changes in state-level availability of reproductive health services — namely closures of Planned Parenthood facilities — were associated with severe maternal morbidity, according to a cross-sectional study published in JAMA Pediatrics.
High-dose tranexamic acid slightly lowers need for blood transfusions in CABG
Among patients undergoing elective CABG, infusion of high-dose tranexamic acid modestly reduced the need for red blood cell transfusion and was noninferior to low-dose infusion regarding safety, findings show.
POISE-3
Tranexamic acid vs. placebo for life-threatening, major and critical organ bleeding in patients undergoing noncardiac surgery.
Tranexamic acid cuts risk for major bleeding following noncardiac surgery
WASHINGTON — Tranexamic acid administered intravenously before and after noncardiac surgery lowered the risk for life-threatening, major and critical organ bleeding compared with placebo, according to results of the POISE-3 trial.
Transfusion dependence, valine gene variant increases mortality risk in VEXAS disease
Patients with VEXAS syndrome who were blood transfusion dependent or had a variant of the valine gene exhibited a threefold increased risk for mortality, according to data presented at ACR Convergence 2021.