Bleeding

Alteplase did not appear to have reduced treatment effect among patients with acute ischemic stroke with one or more cerebral microbleeds, according to an analysis of a randomized clinical trial published in Neurology.

In patients who underwent knee arthroplasty, milvexian, a novel factor XIa inhibitor, was effective at preventing venous thromboembolism and was linked to a low rate of bleeding, researchers reported.

Early CABG performed 2 to 3 days after ticagrelor cessation was noninferior to delayed CABG performed at 5 to 7 days for the outcome of severe or massive perioperative bleeding in patients with ACS who required nonemergent surgery.

In a pooled cohort of the two STOPDAPT-2 trials, among patients who underwent PCI, switching from dual antiplatelet therapy to clopidogrel monotherapy after 1 month reduced bleeding risk compared with 12-month DAPT.

The AGA published clinical practice guidelines in Gastroenterology for the management of coagulation disorders among patients with cirrhosis.

In a subgroup analysis of MASTER-DAPT, regardless of whether patients had a history of MI, 1-month DAPT after PCI was noninferior to 3-month or longer DAPT for ischemic events and conferred a reduction in bleeding events.

In a head-to-head trial of the Amplatzer Amulet and Watchman FLX left atrial appendage closure devices, the primary endpoint of crossover to the other device or residual LAA patency at 45 days was similar, researchers reported at TCT 2021.

Among patients with atrial fibrillation at high risk for stroke, left atrial appendage closure remained noninferior to direct oral anticoagulation for preventing major CV and neurological events out to 4 years.

LAS VEGAS – Balloon-occluded retrograde transvenous obliteration ranked highest as best intervention for gastrointestinal bleeding among other secondary prophylaxis treatments, according to a presenter at the ACG Scientific Annual Meeting.

Rivaroxaban appeared associated with a higher rate of gastrointestinal bleeding than other direct oral anticoagulants, according to study results published in Annals of Internal Medicine.