Bleeding

SAN FRANCISCO — In the REAL-PE study of a real-world population of patients with pulmonary embolism, catheter-directed thrombolysis was associated with reduced risk for major bleeding compared with mechanical thrombectomy.

Transradial access is now the predominant access site for complex, high-risk PCI procedures and is associated with significantly lower risk for mortality, major bleeding and other adverse events compared with transfemoral access, data show.

Anthos Therapeutics announced that the phase 2 AZALEA-TIMI 71 study was stopped early due to an “overwhelming reduction” in bleeding in patients with atrial fibrillation at high risk for stroke taking abelacimab vs. rivaroxaban.

Concizumab prophylaxis reduced bleeding rates among patients with hemophilia A or B with inhibitors, according to results of the phase 3A explorer7 study published in The New England Journal of Medicine.

In the STOPDAPT-3 trial, an aspirin-free strategy after PCI did not reduce major bleeding event risk compared with dual antiplatelet therapy, with data also suggesting a signal for excess coronary events, a speaker reported.

Switching older patients with frailty syndrome and atrial fibrillation to a non-vitamin K antagonist from their old blood thinner caused significant bleeding risk and no greater protection from stroke, a speaker reported.

In flexible bronchoscopy, tranexamic acid appeared comparable to the standard topical hemostatic agent of adrenaline in stopping iatrogenic bleeding, according to results published in CHEST.

Levonorgestrel 52 mg IUD reduces blood loss by more than 90% over 6 months among women with severe heavy menstrual bleeding, according to results of a prospective trial published in Obstetrics & Gynecology.

Among women in Africa with vaginal deliveries, early postpartum hemorrhage detection and use of a bundled treatment intervention lowered risk for severe postpartum bleeding and laparotomy or death from bleeding vs. usual care, data show.

BALTIMORE — A novel etonogestrel drug implant demonstrated effectiveness in treating bothersome bleeding for women using etonogestrel implants for contraception, researchers reported.