Bleeding
Low-dose edoxaban prevents thrombotic events without major bleeding risk in very elderly
In adults aged 80 years and older with atrial fibrillation, once-daily, low-dose edoxaban was superior to placebo for preventing stroke or systemic embolism and did not significantly increase major bleeding in the ELDERCARE-AF trial.
Aspirin only post-TAVR reduces bleeding vs. aspirin plus clopidogrel: POPULAR TAVI
Results from the POPULAR TAVI trial demonstrated that omitting clopidogrel after transcatheter aortic valve replacement may reduce bleeding, and aspirin alone may be sufficient to prevent thromboembolic events, researchers reported.
Bleeding risk, protective effects of aspirin for primary CVD prevention must be weighed
The current literature does not support the use of aspirin for primary prevention in patients with diabetes, and physicians must balance the benefits of prevention with the increased risk for major bleeding, according to a speaker.
Stent platform now indicated for patients with high bleeding risk
Boston Scientific announced that its bioabsorbable polymer stent platform has received a new indication from the FDA to treat patients at high bleeding risk.
NSAIDs increase risk for events after MI
The use of NSAIDs after an MI significantly increased the risk for CV and bleeding events, researchers found.
ACC: Risk assessment, shared decision-making ideal for bleeding from oral anticoagulants
Cardiologists should assess bleeding events in patients taking oral anticoagulation and discuss with them the best approach to minimize future risk, according to an American College of Cardiology expert consensus decision pathway.
Protamine reduces bleeding complications after TAVR
Patients who were administered protamine after transcatheter aortic valve replacement had significantly lower rates of major and life-threatening bleeding complications compared with those without heparin reversal, researchers found.
Clarithromycin, direct oral anticoagulant concomitant use may confer hemorrhagic risk
Among older patients on a direct oral anticoagulant, those who took clarithromycin had a small, statistically significant increased risk for major hemorrhage at 30 days vs. those taking azithromycin, researchers found.
Aspirin doubles risk for upper GI bleeding events in older adults
Aspirin almost doubles the risk for serious upper gastrointestinal bleeding in older people and can further increase with age, smoking, chronic kidney disease and NSAIDs, according to data from Digestive Disease Week.
Frailty increases bleeding risk after TAVR, surgical AVR
Frailty was linked to postprocedural bleeding in older patients undergoing transcatheter aortic valve replacement or surgical AVR, according to a study published in JACC: Cardiovascular Interventions.