Bipolar Disorder

Differences in neurodevelopmental maturation of structural brain networks leave certain adolescents at high genetic risk for bipolar disorder, according to an Australian study published in the American Journal of Psychiatry.

Individuals with serious mental illnesses such as bipolar disorder and schizophrenia may experience greater 10- and 30-year CV risk compared with those without a serious mental illness, researchers reported.

A sublingual film form of the selective alpha-2a-adrenergic receptor agonist dexmedetomidine significantly reduced mild to moderate agitation in patients with bipolar disorder, a phase 3 randomized trial showed.

Alkermes announced positive topline results from its phase 3b study of Lybalvi in young adults with schizophrenia, schizophreniform disorder or bipolar I disorder who were early in their illness.

Sunovion and Otsuka announced the first patient has been randomly assigned in their phase 3 clinical study of non-racemic amisulpride for treating major depressive episodes linked to bipolar I disorder.

Women should be screened and treated for bipolar disorder during pregnancy despite hesitations about pharmacologic treatment, according to a presentation at The Pregnancy Meeting.

Likelihood of inheritance for hypomania, which may lead to bipolar disorder or other mental illnesses, is greater in male twins than in female twins, according to a Swedish cohort study published in JAMA Psychiatry.

Using polygenic risk scores to determine likelihood of parental bipolar disorder passing to offspring is promising but unproven, according to a community-based case-control longitudinal study published in JAMA Psychiatry.

The FDA has approved Caplyta for treating adults with depressive episodes linked to bipolar I or II disorder, according to a company press release.

Adding lithium to usual care for veterans with major depression or bipolar disorders did not reduce incidence of suicide-related events, according to results of a randomized clinical trial published in JAMA Psychiatry.