Bile Acid
Bile Acid Sequestrants
Nonstatins- Evolving Role in ASCVD Prevention
Maralixibat improves pruritis, reduces total serum bile acids in all PFIC subtypes
Maralixibat improved cholestatic pruritis and reduced serum bile acids in pediatric patients with progressive familial intrahepatic cholestasis, regardless of disease genotype, according to data from the MARCH-PFIC trial.
ASSERT: Bylvay outperforms placebo in reducing pruritis, bile acids in Alagille syndrome
Treatment with Bylvay resulted in a “significantly greater” change from baseline to week 24 in mean scratching scores and serum bile acids vs. placebo among pediatric patients with Alagille syndrome, according to ASSERT study results.
Novel therapies targeting bile acid-triggered pathways may benefit children with NASH
Medications that target bile acid-triggered pathways and combination therapies could be the key for treating nonalcoholic steatohepatitis for young people with obesity and type 2 diabetes, according to a speaker.
VIDEO: RBX2660 restores microbiome, bile acid composition in C. difficile infection
SAN DIEGO — RBX2660, an investigational live biotherapeutic, restored microbiome and bile acid composition concurrent with clinical response in patients with Clostridioides difficile, according to research at Digestive Disease Week 2022.