Beta-Cell Dysfunction

A Janus kinase inhibitor may preserve beta-cell function for children and young adults recently diagnosed with type 1 diabetes, according to findings published in The New England Journal of Medicine.

Children with new-onset type 1 diabetes had better preservation of beta-cell function with two 12-day courses of teplizumab compared with those receiving placebo, according to findings published in The New England Journal of Medicine.

When she first enrolled as a freshman undergraduate student at West Virginia University, Carmella Evans-Molina, MD, PhD, never imagined she would become an award-winning diabetes researcher.

PHILADELPHIA — Insulin resistance and beta-cell failure begin long before a diagnosis of prediabetes and aggressive treatment should begin as early as possible to reduce risk for a variety of complications, according to a speaker.

A single 14-day course of the monoclonal antibody teplizumab had lasting effects on delay of type 1 diabetes diagnosis and improved beta-cell function for high-risk individuals, according to new data.

The response to a glucose-potentiated arginine test varied between those with and without obesity among a cohort of adults with type 2 diabetes, particularly in insulin sensitivity and proinsulin secretory ratio, which suggests that beta-cell function is “compromised” in patients without obesity, according to findings published in Diabetes/Metabolism Research and Reviews.

Among a cohort of Japanese adults with type 2 diabetes, HbA1c and fasting plasma glucose fell and beta-cell function rose after a change from exenatide twice per day to exenatide once per week, according to findings published in the Journal of Diabetes Investigation.