Avacincaptad Pegol

The FDA approval of Izervay has provided a second welcomed treatment option for geographic atrophy, with good efficacy and a favorable safety profile.

I do think that complement therapy can be considered for many patients with geographic atrophy, but the risks and benefits need to be thoroughly discussed with the patient.

SAN FRANCISCO — In this Healio Video Perspective from Retina Subspecialty Day at the AAO meeting, Arshad Khanani, MD, MA, FASRS, discusses 2-year results of the GATHER2 trial investigating avacincaptad pegol for geographic atrophy.

The complement component 5 inhibitor avacincaptad pegol may have potential as a treatment to reduce geographic atrophy lesion growth and slow progression of disease, according to a study published in The Lancet.

SEATTLE — A post hoc analysis of the GATHER1 and GATHER2 trials showed the positive effect of avacincaptad pegol treatment in reducing progressive photoreceptor ellipsoid zone attenuation over time.

The European Medicines Agency accepted the marketing authorization application for avacincaptad pegol, according to a press release from Astellas Pharma.

Carl D. Regillo, MD, spoke with Healio about the need for more geographic atrophy treatments.

Carl D. Regillo, MD, spoke with Healio about the use of complement blockers in geographic atrophy.

Another landmark moment in eye care occurred this year with the approval of pegcetacoplan, known as Syfovre from Apellis Pharmaceuticals, allowing treatment for the geographic atrophy form of macular degeneration.