Autoimmune Liver Disease

Aggressive steroid regimens – with doses as high as 60 mg per day – have become the “new mantra” for treating patients with autoimmune hepatitis, according to a presenter at the 2020 Rheumatology Nurses Society Annual Conference.

While the absolute clinical efficacy of ursodeoxycholic acid for primary biliary cholangitis varied by baseline prognostic characteristics, study results showed generally high rates of liver transplant-free survival and overall survival.

CymaBay Therapeutics achieved its targeted patient enrollment for the EHANCE trial, a phase 3 study of seladelpar for primary biliary cholangitis, and that the company is on track to complete full enrollment by the end of November.

SAN ANTONIO — At this year’s National Liver Congress, Gideon M. Hirschfield, MD, presented real-life cases of patients with primary sclerosing cholangitis along with an overview of how autoimmune liver disease may change over time from initial presentation.

SAN ANTONIO — The National Liver Congress will convene October 25th, providing a broad scientific program and exhibit of products and services important for all practitioners involved in the care of patients with liver disease.

Autoimmune liver diseases include primary biliary cholangitis, primary sclerosing cholangitis, and pediatric diseases such as biliary atresia and progressive familial intrahepatic cholestasis. Researchers continue to investigate and develop potential treatments for both the diseases and their debilitating complications.

Long-term treatment with denosumab increased bone mineral density without any adverse effects in patients with autoimmune liver disease, specifically primary biliary cholangitis, according to the results of a pilot study.

Immunic announced the first patient enrolled in a proof-of-concept clinical trial of IMU-838 for the treatment of primary sclerosing cholangitis, according to a press release.

Primary biliary cholangitis poses a significant challenge in hepatology, necessitating effective treatment strategies to improve patient outcomes and quality of life.