Autoimmune Disease

Although a commonly reported complication, cognitive dysfunction associated with rheumatic disease is often “shrouded in this cloud of mystery” for rheumatologists, a presenter said at the 2020 Congress of Clinical Rheumatology-East.

The risk for hospital-diagnosed COVID-19 among patients with autoimmune or immune-mediated disease may depend on age, specific disease and prior therapy, according to data published in the Annals of the Rheumatic Diseases.

Your patient is back — again. She has presented with red, dry eyes for the last 2 years.

Upadacitinib monotherapy, at 15 or 30 mg daily, significantly improves clinical, radiographic and patient-reported outcomes in rheumatoid arthritis, compared with weekly methotrexate, according to data published in Arthritis & Rheumatology.

Patients with juvenile idiopathic arthritis are more likely to develop concurrent autoimmune disease than those with attention deficit hyperactivity disorder, according to data published in Pediatric Rheumatology.

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While FDA- and EU-approved JAK inhibitors have shown comparable efficacy and safety across a spectrum of immune-mediated diseases, more study is required to fully parse the mechanism of action, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit.

A U.S. appeals court has ruled in favor of two patents for Amgen’s etanercept against the biosimilar etanercept-szzs from Novartis’ Sandoz, upholding a prior decision validating claims of patent infringement.

Primary humoral immunodeficiencies appeared significantly associated with psychiatric disorders and suicidal behavior, according to study results published in JAMA Psychiatry.

Kymera Therapeutics has initiated a non-interventional trial evaluating IRAK4 expression in hidradenitis suppurativa and atopic dermatitis, according to a press release.