Atopic Dermatitis

A 1-year-old boy presents with a diffuse rash on the body for the past 3 days (Figures 1 and 2). The rash started on his hands, then progressed to include his face, trunk, buttocks, groin, legs and feet. He also developed low-grade fevers and increased fussiness. He has a history of atopic dermatitis that has been difficult to control with hydrocortisone 2.5% ointment. He attends a day care center three times a week.

Ruxolitinib cream met its primary endpoint in the TRuE-AD2 study in adolescent and adult patients with atopic dermatitis, according to a press release from Incyte.

There is a significant association between postpartum depression and maternal depression and higher odds of childhood atopic dermatitis, according to a prospective cohort study published in Dermatitis.

Some 500 dermatologists will gather in Maui at the end of January for the sixth annual Maui Derm for Dermatologists meeting. If all goes as planned, they will leave the Hawaiian island with actionable strategies to put to immediate use in the clinic.

Observational evidence identified a potential association between atopic dermatitis and an increased risk for keratinocyte carcinoma and kidney cancer, as well as lower odds of lung and respiratory system cancers, according to a meta-analysis in JAMA Dermatology.

Upadacitinib reduced all clinical disease measures including itch-related outcomes at 16 weeks in patients with moderate to severe atopic dermatitis, according to phase 2b study results published in Journal of Allergy and Clinical Immunology.

LEO Pharma announced that tralokinumab met all primary and secondary endpoints in ECZTRA 1-3, its three pivotal phase 3 studies for moderate to severe atopic dermatitis in adults.

Preliminary findings from Emma Guttman-Yassky, MD, PhD, and colleagues demonstrate a novel use of dupilumab for managing chronic keloids with reductions in skin fibrosis and keloidal scarring, which may suggest a potential underlying Th2 pathogenesis in keloid formation.

Researchers discovered a method to evaluate the cutaneous biomarkers of atopic dermatitis using minimally invasive tape strips, which may offer insight into tracking pediatric treatment responses in the future, in the top pediatric dermatology story at Healio.