Aspirin
Aspirin doubles risk for upper GI bleeding events in older adults
Aspirin almost doubles the risk for serious upper gastrointestinal bleeding in older people and can further increase with age, smoking, chronic kidney disease and NSAIDs, according to data from Digestive Disease Week.
Regular aspirin use may reduce risk for colorectal, other digestive tract cancers
Regular use of aspirin appeared to reduce the risk for several digestive tract cancers, according to results of a meta-analysis published in Annals of Oncology.
Some CV medications prescribed less often to women than men
Women with established CVD had lower rates of prescriptions for statins, aspirin and ACE inhibitors compared with men, according to a systematic review and meta-analysis published in the Journal of the American Heart Association.
VOYAGER-PAD
Low-dose rivaroxaban (Xarelto, Bayer/Janssen) twice daily plus aspirin vs. placebo plus aspirin in PAD.
CAC may best risk score for decisions on aspirin for primary prevention
Using coronary artery calcium scores may better define who should receive aspirin for primary prevention than using the Pooled Cohort Equations, researchers reported in Circulation.
Low-dose rivaroxaban reduces risk in PAD post-revascularization
In the VOYAGER PAD trial, patients with symptomatic peripheral artery disease who underwent lower-extremity revascularization had a lower incidence of major adverse limb and CV events compared if treated with low-dose rivaroxaban twice daily plus aspirin, compared with aspirin only.
Aspirin may reduce risk for hepatocellular carcinoma, liver-related mortality in chronic viral hepatitis
Low-dose aspirin use appeared associated with significantly lower risk for hepatocellular carcinoma and lower liver-related mortality among patients with chronic viral hepatitis, according to results of a retrospective study published in The New England Journal of Medicine.
Aspirin nonadherence elevates risk for preeclampsia, preterm delivery in high-risk pregnancy
High-risk pregnant women who were nonadherent to prescribed aspirin experienced greater risk for poor clinical outcomes compared with women who were adherent, according to research published in Hypertension.
Low-dose aspirin reduces risk for preterm birth in first-time moms
Taking low-dose aspirin as early as 6 weeks’ gestation could reduce the risk for preterm birth among first-time mothers, according to results from a randomized clinical trial published in The Lancet.
Top-line THALES results: Ticagrelor plus aspirin effective for secondary stroke prevention
AstraZeneca announced that in the phase 3 THALES study, in patients with minor acute ischemic stroke or high-risk transient ischemic attack, twice daily ticagrelor 90 mg plus aspirin met the primary endpoint of reduced risk for stroke and death at 30 days compared with aspirin alone.