Apolipoprotein

Consumption of certain teas and coffee may have positive effects on neural network maintenance that could bode well for the prevention of symptoms indicative of Alzheimer’s disease, according to research published in Nutrients.

PHILADELPHIA — In patients with post-transplant collapsing glomerulopathy, a similar portion of donors had one or two apolipoprotein L1 kidney risk variants, whereas few had none.

Apolipoprotein L1 genotype may not be a major factor for future risk of kidney disease in middle-aged adults, according to data from a longitudinal cohort study.

Patients who eventually developed giant cell arteritis demonstrated significantly higher levels of apolipoprotein A-I at baseline, according to population-based data published in Arthritis Research & Therapy.

Pegozafermin, a fibroblast growth factor 21 analog, reduced atherogenic particles in patients with severe hypertriglyceridemia and improved liver fat and insulin resistance compared with placebo, a speaker reported.

A unanimous U.S. Supreme Court decision has allowed Regeneron and Sanofi to continue selling alirocumab after Amgen alleged they infringed two of its patents for PCSK9 inhibitor technology.

Regardless of proteinuria, the presence of a high-risk apolipoprotein L1 genotype in patients with chronic kidney disease correlates with an increased risk of kidney failure, according to data published in Kidney Medicine.

CHICAGO — Olpasiran, a small interfering RNA agent directed to the liver, yielded substantial and sustained reductions in lipoprotein(a) concentrations among patients with established atherosclerotic CVD in the phase 2 OCEAN(a)-DOSE study.

In a phase 2 trial, obicetrapib, an investigational cholesteryl ester transfer protein inhibitor, decreased LDL, non-HDL, lipoprotein(a) and apolipoprotein B and increased HDL at 8 weeks, researchers reported in Nature Medicine.

In a cohort of more than 16,000 Hispanic/Latino Americans, there was heterogeneity in lipoprotein(a) and apolipoprotein B levels according to background, researchers reported at the National Lipid Association Scientific Sessions.