Antiphospholipid Syndrome
Alternative complement pathway inhibition may be key to lupus management
The next therapeutic innovation in complement biology therapies for rheumatic diseases may involve inhibiting the alternative complement pathway, according to a speaker at the Biologic Therapies Summit.
Cutaneous involvement ‘frequent’ in patients with catastrophic antiphospholipid syndrome
About half of the patients with catastrophic antiphospholipid syndrome have cutaneous involvement, which can help predict outcomes in this condition, according to a study.
CATCR-T cell therapy may aid in antiphospholipid syndrome through selective B-cell depletion
PHILADELPHIA — Upcoming T-cell therapies may treat antiphospholipid syndrome and other autoimmune diseases without compromising a patient’s defenses against infection, according to data presented at ACR Convergence 2022.
Vitamin K antagonists may be best treatment option in thrombotic antiphospholipid syndrome
CHICAGO — In patients with thrombotic antiphospholipid syndrome, vitamin K antagonists were linked to lower odds of arterial thrombotic events compared with direct oral anticoagulants, according to a meta-analysis.
Immunologic strategies for antiphospholipid syndrome still yield ’not great results’
SAN DIEGO — Primary prevention remains the biggest treatment challenge in antiphospholipid syndrome, according to a speaker at the Congress of Clinical Rheumatology West.
Q&A: ‘Primary prevention’ the biggest challenge in managing antiphospholipid syndrome
Reducing the risk for thrombotic events in patients with antiphospholipid syndrome means striking the proper balance of monitoring and anticoagulation therapy, according to Richard A. Furie, MD, of Northwell Health in New York.
Q&A: Non-criteria manifestations of pediatric APS common yet ‘under-recognized’
Peer-reviewed papers on pediatric antiphospholipid syndrome do not appear very often.
Fetal heart rate monitoring feasible, accurate in anti-Ro/SSA antibody positive pregnancy
Heart rate monitoring may be a crucial means of detecting rhythm abnormalities in the fetuses of pregnant individuals who are positive for anti-Ro/SSA antibodies, according to data presented at ACR Convergence 2021.
Thrombocytopenia predicts thrombosis risk, poor survival in antiphospholipid syndrome
Persistent low-to-moderate thrombocytopenia can identify patients with antiphospholipid syndrome who are at high risk for thrombosis, and is linked to poor long-term survival, according to data published in Rheumatology.
Antiphospholipid syndrome management rife with theoretical, imperfect therapies
Preventing a first clotting event with aspirin may be the only truly effective treatment option in antiphospholipid syndrome, according to a presenter at the 2021 Congress of Clinical Rheumatology-East.