Antidepressant

Anthony Lembo, MD, Director of Research for Cleveland Clinic's Digestive Disease & Surgery Institute, discusses the diagnostic process for patients presenting with constipation; approaching management of patients with IBS-C and CIC; treatment options and recent therapeutic advances; health disparities; and important challenges of care.

In older adults with treatment-resistant depression, antidepressant augmentation improved well-being significantly over 10 weeks compared with switching medications and was associated with higher incidence of remission.

In an update to its guidance on depression, ACP now recommends cognitive behavioral therapy or second-generation antidepressants as an initial treatment for patients in the acute phase of moderate to severe major depressive disorder.

Antidepressant use in pregnancy was not associated with neurodevelopmental disorders in offspring, according to a cohort study published in JAMA Internal Medicine.

NEW ORLEANS – Patients who received cariprazine in addition to their standard antidepressant showed clinical improvement for depression, Gary Sachs, MD, said at the American Psychiatric Association annual meeting.

Using serotonergic antidepressants during the first trimester of pregnancy did not increase the risk for neonatal seizures or epilepsy, according to data published in Neurology.

Patients with a previous cesarean delivery who failed a trial of labor were more likely to be using antidepressants 6 weeks postpartum compared with those who had a successful trial of labor.

Patients with confirmed COPD had an increased risk for depression and were more likely to receive a prescription for antidepressant medication than individuals without COPD, according to data published in Respiratory Medicine.

Healio’s most-viewed psychiatry stories in February highlight a study on antidepressant combination therapies, updates in ADHD treatments and the pandemic’s impact on those with mood and anxiety disorders.

Combination therapy that included an antagonist of presynaptic alpha2-autoreceptors appeared effective and safe for patients with depression who did not respond to monotherapy, according to a report published in JAMA Psychiatry.