Antibiotic

There was a short-term increase in selection for resistance in Streptococcus pneumoniae among children who received azithromycin during a mass administration of the antibiotic, but no evidence of long-term resistance, a study found.

A recent study adds to growing data showing that oral antibiotics are as good as IV antibiotics in periprosthetic joint infection, and the data show that an early switch can be considered in the right scenario.

Nonoperative management of patients with acute, uncomplicated appendicitis is comparable to surgical treatment in safety and efficacy, although longer hospital stays and recurrence are possible, according to a meta-analysis in JAMA Surgery.

Recurrent bacterial vaginosis (BV) impacts quality of life, but treatment is currently limited to repeated courses of antibiotics.

Using anti-Pseudomonas aeruginosa antibiotics may not provide additional benefit for children with cystic fibrosis who were culture negative for P. aeruginosa for at least 1 year, researchers reported.

Procalcitonin-guided care reduced antibiotic use without increasing the risk for infection among patients with acute pancreatitis compared with standard care, according to research published in The Lancet Gastroenterology and Hepatology.

Combining the corticosteroid fluocinolone acetonide with ciprofloxacin was safe and efficacious in treating swimmer’s ear, although it was not superior to treatment with either agent alone, according to a study published in JAMA Network Open.

Outpatient antibiotic management was safe compared with in-hospital care, with no greater risk for complications or appendectomy, in a subgroup of patients with acute appendicitis, according to research.

The use of broad-spectrum antibiotics in the month leading up to chimeric antigen receptor T-cell therapy led to poorer outcomes and increased treatment-related toxicities, study results showed.

Empiric gram-negative antibiotic use varied significantly across the United States, with high inter-hospital variability, according to a recent study published in Clinical Infectious Diseases.