Anaphylaxis

An asthma diagnosis, loss of consciousness and higher basal tryptase levels may be indicators of a biphasic anaphylactic reaction, according to a letter published in Clinical and Translational Allergy.

Two children with severe cow’s milk allergy developed anaphylactic reactions after receiving doses of a measles, mumps and rubella — or MMR — vaccine that included the alpha-lactoglobulin component of milk, researchers reported.

Anaphylaxis may occur to low-level cow’s milk exposure among approximately 5% of allergic individuals reacting to these doses, according to a study in The Journal of Allergy and Clinical Immunology.

Sesame-induced anaphylaxis, usually due to hummus ingestion, common represented the first manifestation of sesame allergy among children in Canada, according to a study published in Annals of Allergy, Asthma & Immunology.

Although current guidelines recommend calls to emergency medical services and ED visits in response to anaphylaxis, home management may be preferable in many cases, according to a literature review.

Significant knowledge gaps make it difficult to accurately identify risk factors and predict the severity of allergic reactions to food, according to a review published in Allergy.

Legume allergies appeared more common among children with multiple food allergies, and most of these children were allergic to multiple legumes, according to a study conducted in Turkey and published in Pediatric Allergy and Immunology.

Researchers confirmed that epinephrine can reach therapeutic plasma concentrations via sublingual administration during the second part of the ongoing EPIPHAST study conducted by Aquestive Therapeutics.

Programs that increase access to epinephrine autoinjectors to treat anaphylaxis caused by food allergies, along with training in using them, need to be expanded, according to a review published in Annals of Allergy, Asthma & Immunology.

Patients with typical cold urticaria should be screened for cold-induced anaphylaxis risks and prescribed adrenaline autoinjectors, according to a study published in Allergy.