Anakinra

Anakinra, an interleukin-1R antagonist, was shown to be a safe treatment in patients with acute myocarditis, but did not change the number of days free from complications compared with placebo, a speaker reported.

WASHINGTON — Prednisone induced a higher 90-day survival rate and lower incidence of acute kidney injury compared with anakinra and zinc sulfate in patients with severe alcohol-associated hepatitis, according to late-breaking data.

DENVER — The interleukin-1 inhibitor anakinra has little to no effect on moderate to severe multisystem inflammatory syndrome in children, according to researchers.

A subset of patients with Still’s disease develop drug reactions with eosinophilia and systemic symptoms to interleukin-1 and IL-6 inhibitors, with strong associations among those with common HLA-DRB1*15 haplotypes, according to data.

Reviewing old data and challenging conventional wisdom may yield benefits in managing gout flares, according to a presenter at the 2021 Congress of Clinical Rheumatology-West.

Anakinra safely reduces the need for invasive mechanical ventilation and mortality risk in patients with COVID-19 who are hospitalized, but non-intubated, according to a meta-analysis published in Rheumatology.

Steroids are commonly used to mitigate severe treatment-related adverse events associated with chimeric antigen receptor T-cell therapy.

Pre-existing conditions can help distinguish between multisystem inflammatory syndrome and COVID-19 pneumonia in pediatric patients, according to experts.

Although anakinra is not superior to triamcinolone in affecting gout pain intensity over 24 to 72 hours, it is comparable in pain reduction and even favored in most secondary outcomes, according to data published in Arthritis & Rheumatology.