Alzheimer's Disease

Increased expression of various X chromosome genes had different impacts on tau burden and cognition in men and women with and without Alzheimer’s disease, according to a study in JAMA Neurology.

Neuropsychiatric and cognitive symptoms were common across the Alzheimer’s disease continuum but evolved differently during the course of the disease, according to results of a single-center observational study published in Neurology.

The FDA approval of Aduhelm, which was based on beta amyloid as a surrogate endpoint, represented a “regulatory failure,” according to members of an advisory committee convened by the FDA in November 2020.

Dipeptidyl peptidase-4 inhibitor use in patients with diabetes and Alzheimer’s disease-related cognitive impairment correlated with lower amyloid burden and favorable long-term cognitive outcome, according to a study in Neurology.

Physical activity correlated with slower cognitive decline among people with both high and low tau concentrations, according to a population-based cohort study in JAMA Network Open.

Neurodegenerative disease diagnoses occurred more often among former soccer players than the general population, with defenders experiencing the highest risk, according to results of a cohort study published in JAMA Neurology.

Healio Psychiatry has compiled a list of its five most-viewed stories in July.

In a recent study, the age that women reached menopause and the type of menopause experienced appeared to impact their cognition as they grew older.

Unmet need was high among patients with Alzheimer’s disease and related dementias during the COVID-19 pandemic, according to study results presented at the Alzheimer’s Association International Conference.

The online tool Outreach Pro was launched at the Alzheimer’s Association International Conference to raise awareness of clinical trials for Alzheimer’s disease and other dementias, specifically in “traditionally underrepresented communities.”