Allogeneic Transplantation

The 2-year OS rate nearly doubled during the past 2 decades among patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who relapsed after allogeneic hematopoietic stem cell transplantation, according to study results.

Inotuzumab ozogamicin was well tolerated among patients with acute lymphoblastic leukemia who had undergone allogenic transplantation in a small study.

In this video, Joshua Sasine, MD, PhD, assistant professor of medicine hematology and cellular therapy at Samuel Oschin Cancer Center Regenerative Medicine Institute, discusses new allogeneic chimeric antigen receptor T-cell therapy data.

The FDA approved abatacept in combination with a calcineurin inhibitor and methotrexate for prevention of acute graft versus host disease.

The FDA approved ruxolitinib for treatment of certain patients with chronic graft-versus-host disease.

Post-transplant cyclophosphamide reduced incidence of graft-versus-host disease but led to higher incidence of early cardiac events after allogeneic hematopoietic stem cell transplantation, according to study results.

As targeted therapies and novel treatments emerge, allogeneic hematopoietic cell transplantation has taken a backseat to immunotherapy in the treatment of lymphoma.

Peter Abdelmessieh, DO, MSc, has joined the department of bone marrow transplant and cellular therapies at Fox Chase Cancer Center.

Allogeneic hematopoietic cell transplantation showed potential in patients with high-risk multiple myeloma, according to findings presented at the ASCO Annual Meeting.

The FDA granted priority review to ruxolitinib for the treatment of adults and children aged 12 years or older with steroid-refractory chronic graft-versus-host disease, according to a manufacturer-issued press release.