Adverse Drug Event
Adverse events increase with age, body weight in pediatric patients with plaque psoriasis
As age and body weight increased among secukinumab-treated pediatric patients with chronic plaque psoriasis, so did the incidence rate of adverse events, according to pooled safety data from two phase 3 studies.
Q&A: Too much CBD could be bad for the liver
A recent systematic review and meta-analysis revealed that moderate to high doses of cannabidiol were associated with liver enzyme elevation and drug-induced liver injury, meeting the criteria of common adverse drug events.
Serious adverse events rare among adults receiving tirzepatide in clinical trials
More than one-third of adults receiving tirzepatide in clinical trials experience gastrointestinal adverse events, but adverse events leading to drug discontinuation were rare, according to study data.
Guselkumab’s safety profile consistent regardless of TNF-inhibitor use in psoriatic arthritis
The 2-year safety profile of guselkumab appears consistently favorable across patients with psoriatic arthritis who are either naïve or experienced with TNF inhibitors, according to data published by The Journal of Rheumatology.
Review of meeting abstracts shows toxicity reporting inconsistent, incomplete
Toxicity reporting in certain abstracts presented in recent years at ASH Annual Meeting and Exposition appeared inconsistent and incomplete, according to a systematic review.
Osimertinib-related pneumonitis incidence higher in real-world lung cancer population
Drug-related pneumonitis occurred among 18% of patients receiving osimertinib for advanced epidermal growth factor receptor mutation-positive non-small cell lung cancer, according to study results published in CHEST.
‘No new safety concerns’ emerge for ocrelizumab in MS subpopulations
Continuous administration of ocrelizumab in clinical trials and its broader use in real-world settings exhibited a favorable and manageable safety profile for relapsing MS and primary progressive MS, according to a study in Neurology.
Nitrates top list of medications that trigger headaches, analysis shows
Nitrates were the most frequent cause of medication-induced headaches, according to an analysis of more than 2.6 million records in the FDA’s Adverse Event Reporting System.
Q&A: Discussing potential adverse events of new medications with older adults
Many older adults do not recognize potential adverse events associated with their new medications, according to a study published in the Journal of General Internal Medicine.
Patients with CLL face ‘substantial burden’ of adverse events in real-world treatment setting
ORLANDO — Adverse events from treatment for chronic lymphocytic leukemia appeared common among Medicare patients treated in a real-world setting, which contributed to a substantial economic burden for these patients, according to results of a population-based retrospective cohort study presented at ASH Annual Meeting and Exposition.