Adrenal Insufficiency
DHEAS may serve as biomarker for diagnosing adrenal insufficiency
The use of dehydroepiandrosterone sulfate to determine an adrenal insufficiency diagnosis has similar accuracy to using baseline cortisol level, according to findings published in The Journal of Clinical Endocrinology & Metabolism.
Relacorilant improves cardiometabolic metrics for patients with Cushing’s syndrome
Among patients with endogenous hypercortisolism, relacorilant improved cardiometabolic parameters such as blood pressure, HbA1c and weight, according to results of a long-term extension study.
Inhaled corticosteroids for asthma may increase risk for adrenal suppression
SAN DIEGO — Plasma metabolite profiles were significantly associated with cortisol levels among patients with asthma who use inhaled corticosteroids, according to a poster at the American Thoracic Society International Conference.
New joint guideline focuses on treatment of glucocorticoid-induced adrenal insufficiency
Glucocorticoid tapering, education and treatment of adrenal crisis are three of the main focuses of a new clinical practice guideline on glucocorticoid-induced adrenal insufficiency.
Investigational Cushing’s syndrome medication reduces BP, glucose in open-label trial
Adults with endogenous Cushing’s syndrome had reductions in blood pressure and glucose at 22 weeks of treatment with a selective cortisol modulator, according to topline results from the open-label portion of the GRACE phase 3 trial.
Addressing glucocorticoid withdrawal syndrome in treatment of Cushing’s syndrome
To achieve optimal outcomes in Cushing’s syndrome, both clinicians and patients need to be prepared for the type and duration of symptoms that patients may experience during treatment and recovery.
Oral, inhaled corticosteroids associated with risk for adrenal insufficiency
Cumulative exposure to glucocorticoids appeared associated with risk for adrenal insufficiency among patients with severe asthma, according to a study published in The Journal of Allergy and Clinical Immunology: In Practice.
Mortality rate in Cushing’s syndrome ‘unacceptably high’
A large study of mortality in Cushing’s syndrome calculated a threefold higher mortality rate for these patients, with cerebrovascular and atherosclerotic vascular diseases and infection accounting for 50% of deaths, researchers reported.
Seeking better pharmaceuticals: A conversation with Richard J.M. Ross, MD, FRCP
Richard J.M. Ross, MD, FRCP, professor of endocrinology in the department of oncology and metabolism at the University of Sheffield in the United Kingdom, has taken a different career path than most in his field.
Severe COVID-19 risks greatly increased for children with adrenal insufficiency
Adrenal insufficiency increases the risk for severe outcomes, including death, 23-fold for children who contract COVID-19, according to a data analysis presented at the ENDO annual meeting.