Scleroderma News

Higher blood neutrophil count and neutrophil-to-lymphocyte ratio predict more severe disease and increased mortality in patients with systemic sclerosis, according to data published in Arthritis Care and Research.

The FDA has granted orphan drug designation to Gesynta Pharma’s GS-248, an oral small molecule, selective membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor, for systemic sclerosis, according to a company press release.

The FDA has granted an orphan drug designation for biotherapeutics firm aTyr’s potential first-in-class immunomodulator efzofitimod in the treatment of systemic sclerosis, according to a company press release.

Rilzabrutinib induced rapid and durable clinical activity in previously treated patients with immune thrombocytopenia, according to results of a phase 1/phase 2 clinical trial published in The New England Journal of Medicine.

Patients with rheumatic and musculoskeletal diseases should engage in both aerobic and strengthening exercises, aiming for at least moderate intensity, according to new EULAR recommendations.

March is Autoimmune Awareness Month, and rheumatology organizations have been using their reach and influence on social media sites to spread the word and help patients with autoimmune diseases find community.

The last 3 years of drug development in scleroderma have come to represent everything that ails the current pipeline for that disease.

Nintedanib reduces the rate of forced vital capacity decline more significantly in patients with systemic sclerosis-associated interstitial lung disease who reported no dyspnea or cough at baseline, data show.

Cytokine profiles can distinguish patients with systemic sclerosis who are at high risk for, or have, pulmonary arterial hypertension from those with low risk and healthy controls, according to data published in Arthritis Research & Therapy.

Diastolic dysfunction is an independent risk factor for increased mortality risk among patients with systemic sclerosis, according to a study published in Arthritis & Rheumatology.