July 03, 2019
25 min listen
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IgG4-related Disease with John Stone, MD
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John Stone, MD, MPH, is the world leader in the field of IgG4-related disease research. In this episode, he breaks down the histology of IgG4-related disease, important aspects of what is known about the pathophysiology of the disease, as well as future directions in treatment.
- Intro :10
- Inside this episode :13
- IgG4-related disease background :31
- An anecdote 1:15
- The interview 4:09
- History of IgG4-related disease 4:18
- IgG4 pathology and terms 7:48
- What makes IgG4 different from other IgG subclasses? 10:23
- What do we know about the interplay between B and T cells? 12:31
- What is SLAMF7? 16:30
- What happens to T cells during B-cell depletion? 18:22
- Antigens involved in IgG4 21:06
- Future of treatment 23:10
- Thank you, Dr. Stone 24:32
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John Stone, MD, MPH, is director of clinical rheumatology at Massachusetts General Hospital.
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