Pulmonary hypertension, part 3: Early therapies and vascular physiology
In this episode, we dive into the early therapies and how our understanding of vascular physiology drastically changed the management of pulmonary hypertension.
- Intro 0:12
- In this episode 0:18
- Recap of part 1 & 2 0:31
- What part 3 is about 2:31
- WHO conference in 1975: Treating pulmonary hypertension 3:48
- The Discovery of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), Part 1 5:20
- Epoprostenol 6:18
- Prostacyclin 10:37
- Endothelin antagonists 11:41
- Phosphodiesterase type 5 (PDE5) inhibitors 14:08
- Interaction of nerves and blood vessels 15:06
- The Soups VS the Sparks 17:36
- A dreamed experiment 19:06
- Acetylcholine 23:23
- Enter “the calabar bean” 24:45
- Acetylcholine and vasodilation: 1976 26:01
- Rabbit aorta 27:45
- Nitric oxide 29:38
- Why are we using nitric oxide to treat pulmonary hypertension? 31:31
- Tachyphylaxis 33:48
- TNT factories 35:09
- Nitrous oxide and tachyphylaxis 36:52
- Pfizer in the 1980s 38:06
- Understanding the trigger of pulmonary hypertension 40:53
- PDE5 and nitric oxide and pulmonary hypertension 43:07
- The end of the ripping yarns 44:20
- Coming up in part 4 46:17
- Thanks for listening 47:29
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
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