ByAdam J. Brown, MD

July 29, 2021

32 min listen

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A Sickness in the Serum, Part 3: The Search for Immune Complexes

ByAdam J. Brown, MD

The final episode in this trilogy delves into the advancement in lab techniques that allowed for more accurate measurements of immune complexes, leading to studies that clearly demonstrated the potential pathogenicity of immune complex-mediated disease.

Brought to you by GSK.

Intro :20
Recap and in this episode :40
The precipitant reaction 3:29
The antibody story 11:25
Dr. Frank Dixon 18:20
When did people start using these techniques? 20:15
On the quest to see if immune complexes are pathogenic 24:09
Frank Dixon’s findings using radioactive iodine tagging 28:22
Episode wrap-up 29:00
Thanks for listening! 32:11

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Germuth FG Jr, et al. Johns Hopkins Med J. 1967;120:225-251.

Kano K, Milgrom F. Vox Sanguinis. 1980;38:121-137.

McCluskey RT, et al. J Exp Med. 1960;111:181-194.

Waksman BH. Medicine (Baltimore). 1962;41:93-141.

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Sources/Disclosures

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Disclosures: Brown reports no relevant financial disclosures.

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