Whipple’s Disease: When Should a Rheumatologist Take a Whiff of Whipple’s?
This episode dives into the rare Whipple’s disease, focusing on the articular manifestations of this infectious masquerader and when a rheumatologist should consider it in the differential.
Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com.
- Intro :20
- In this episode :28
- Background on the organism 5:25
- An important point when making the diagnosis 7:48
- Who gets infected? 8:55
- What is Whipple’s disease? 11:48
- This disease is fatal 15:53
- A look at the joints 16:28
- What happens when you give these patients immunosuppression? 26:36
- How to diagnose 28:38
- Summary so far 31:00
- Other organ manifestations of Whipple’s disease 32:08
- Summary and take-home 44:36
Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com
Disclosure: Brown reports no relevant financial disclosures.
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References:
Bousbia S, et al. Emerg Infect Dis. 2010;16:258-63.
Chan RY, et al. Ophthalmology. 2001;108:2225-2231.
Dobbins 3rd WO, et al. Arthritis Rheum. 1987;30:102-105.
Durand DV, et al. Medicine (Baltimore). 1997;76:170-84.
Fenollar F, et al. BMC Infect Dis. 2011;11:171.
Feurle GE, et al. Eur J Clin Invest. 1979;9:385-389.
Geissdörfer W, et al. J Clin Microbiol. 2012;50:216-22.
Guérin A, et al. Elife. 2018;7:e32340.
Heffner DK. Lancet. 2007;370:738-9; author reply 739.
Keita AK, et al. PLoS Negl Trop Dis. 2011;5:e1403.
Lagier JC, et al. Medicine (Baltimore). 2010;89:337-345.
Lozupone C, et al. Am J Respir Crit Care Med. 2013;187:1110-7.
McAllister Jr. HA, Fenoglio Jr. JJ. Circulation. 1975;52:152-6.
O’Duffy JD, et al. Arthritis Rheum. 1999;42:812-817.
Puéchal X. Joint Bone Spine. 2016;83:631-635.
Puéchal X, et al. Arthritis Rheum. 2002;46:1130-1132.
Puéchal X, et al. Arthritis Rheum. 2007;56:1713-1718.
Raheja AA, et al. Clin Imaging. 2010;34:143-147.
Ramos JM, et al. J Med Case Rep. 2015;9:165.
Raoult D, et al. Emerg Infect Dis. 2010;16:776-82.
Schöniger-Hekele M, et al. Appl Environ Microbiol. 2007;73:2033-2035.
Stein A, et al. Am J Respir Crit Care Med. 2013;188:1036-7.
Additional resource:
Neurosigns.org’s video on oculomasticatory myorhythmia can be viewed at: https://www.youtube.com/watch?v=Zwb5bt749Jo
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