Osteoarthritis and Bone Disorders News

Postmenopausal women with osteoporosis who stop taking the monoclonal antibody denosumab risk a rapid loss of any bone mineral density gains and an increase in bone turnover markers, and should consider alternative therapies or avoiding a drug holiday, according to findings from a systematic review.

Bisphosphonates and denosumab increased bone mineral density in men with nonmetastatic prostate cancer who received androgen deprivation therapy, according to findings published in Annals of Internal Medicine.

Power Doppler ultrasound-detected synovitis is strongly predictive of short-term psoriatic arthritis flare among patients in clinical remission, according to findings.Researchers evaluated 52 consecutive patients with psoriatic arthritis based on the CASPAR criteria and who were in clinical remission. A musculoskeletal examination was conducted and a rheumatologist with experience in ultrasound (US) conducted imaging assessments on the same day as clinical assessment. The rheumatologist was blinded to the clinical data and evaluated 18 joints per patient. Follow-up continued for 6 months to monitor disease flares.

Chronic nonbacterial osteomyelitis responds well to treatment in the first year, but demonstrates high rates of relapse in long-term follow-up, according to findings.

Wide variation exists in the definitions of osteoarthritis flare currently in rheumatology trials, which negate the value of direct comparison between trials and impede interpretation of evidence, according to recent findings.

Moderate alcohol consumption was linked with severity of hand osteoarthritis, according to a recently published study.

Improved self-efficacy regarding exercise and more positive exercise expectations were linked with increased current and future levels of physical activity among patients aged 45 years or older with osteoarthritis-related pain, according to a recently published study.

VIENNA — In patients who undergo total knee replacement, retention of the infrapatellar fat pad is associated with better functional outcomes and less postoperative pain, according to a study presented here during the Free Papers Award Session for Orthopaedics at the 18th EFORT Annual Congress in Vienna.

Agmen recently submitted a supplemental Biologics License Application to the FDA for denosumab for the treatment of people with glucocorticoid-induced osteoporosis, according to a company press release.

Among adults with diabetes, an intensive lifestyle intervention and diet may prevent knee pain, according to a recently published study.