Lupus News

Early treatment with mycophenolate mofetil can reduce subsequent risks for severe flares and lupus nephritis in newly diagnosed systemic lupus erythematosus, according to data published in JAMA Network Open.

The FDA has cleared an investigational new drug application allowing a novel bispecific T-cell engager to begin a phase 1 trial in patients with active, moderate-to-severe systemic lupus erythematosus, according to a press release.

Among pregnancies in patients with systemic lupus erythematosus, those with small for gestational age infants were significantly more likely to demonstrate increased perivillous fibrin deposition in the placenta, according to data.

Advanced structural MRI can detect brain abnormalities linked with cognitive dysfunction in patients with systemic lupus erythematosus, according to a systematic review published in Lupus Science & Medicine.

A recent investigation into the molecular roots of systemic lupus erythematosus may point the way toward a new generation of therapeutic targets, according to the researchers.

Kezar Life Sciences has paused a phase 2b trial of zetomipzomib in active lupus nephritis after reporting four patient deaths, according to a press release from the manufacturer.

SAN DIEGO — Obinutuzumab and ianalumab are two promising B-cell depleting therapies on the horizon for lupus, according to data presented at the 2024 Congress of Clinical Rheumatology West.

SAN DIEGO — New imaging technologies, and improved use of the ones currently available, may move rheumatology closer to precision medicine in inflammatory arthritis, according to a speaker at the 2024 Congress of Clinical Rheumatology West.

SAN DIEGO — Regulatory trials of chimeric antigen receptor T-cell therapies for autoimmune diseases could be successful with a focus on patients with severe disease and strict endpoints, according to a speaker.

Dapirolizumab pegol met its primary endpoint, achieving clinical improvement, when combined with standard-of-care treatment for moderate-to-severe systemic lupus erythematosus, according to topline results announced by its manufacturers.