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Intra-articular injection of HA linked with reduced cartilage degradation serum levels in knee OA
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Recently published results showed a reduction in Coll2-1 serum levels after an intra-articular injection of reticulated hyaluronic acid with mannitol in patients with knee osteoarthritis.
Researchers randomly assigned 81 patients (69.1% were women) with symptomatic knee osteoarthritis (OA) to receive either an intra-articular injection of hyaluronic acid (HA) with mannitol (Kartilage Cross, Vivacy) or a saline solution. The percentage of patients with a reduction of at least 10 nmol/l of serum Coll2-1, a degradation product of type II collagen, between baseline and day 90 was the primary outcome. Secondary outcomes included clinical evaluation and tolerance of the HA.
Sensitivity analysis showed 56.8% of patients in the HA group had a decrease in the levels of serum Coll2-1 between inclusion and 90 days after injection vs. 28.6% of patients in the placebo group. Without considering the missing data, researchers found the same statistically significant difference among the per protocol population. No significant differences were found in changes in function or pain and on the number of adverse events between groups, according to results. – by Casey Tingle
Disclosures: Henrotin reports he is the founder of Artialis SA a spin-off company of the University of Liège and received fees from Flexion, Ibsa, Expansciences, KiOmed Pharma SA, Tilman SA, Bepharbel and Labhra. Please see the full study for a list of all other authors’ relevant financial disclosures.
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