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Study: Metabolic syndrome not linked with hand OA
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LAS VEGAS — A study presented here at the Osteoarthritis Research Society International World Congress indicated no significant relationship between metabolic syndrome and hand osteoarthritis.
Using the Framingham offspring cohort, Ida Kristin Haugen, MD, PhD, from Diakonhjemmet Hospital in Norway, and colleagues assessed 1,089 patients. Of these, 22.5% had hand osteoarthritis (OA) and 41.5% had metabolic syndrome (MetS). Among 785 patients who had 7-year longitudinal hand radiographs, 51.5% had radiographic change.
Researchers found no association between hand OA and MetS in cross-sectional analyses. However, among the components of MetS, there was an association for hypertension with hand OA (ratio = 1.75, after adjustments for age, sex and BMI). Among those without hand OA at baseline, 25.8% developed hand OA at follow-up; however, investigators found no link between MetS and change in Kellgren-Lawrence score or incident hand OA. Despite this, hypertension was associated with a change in Kellgren-Lawrence score (ratio = 1.47), although there was no dose-dependent relationship in terms of change in systolic blood pressure and there was no association with incident hand OA. In addition, there was an association with central obesity; although, this did not carry significance when investigators performed a cross-sectional analysis. Also, there were no associations with erosive hand OA, according to the study abstract.
Reference:
Haugen IK, et al. Paper #86. Presented at: Osteoarthritis Research Society International World Congress; April 27-30, 2017; Las Vegas.
Disclosure: The researchers report no relevant financial disclosures.