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Meta-analysis: Histopathologic classification of AAV can determine renal outcomes
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Histopathologic classification can determine renal outcomes in patients with antineutrophil cytoplasmic antibodies-associated vasculitis, according to data from a recently published meta-analysis of 1,601 patients.
Yong-Xi Chen, MD, at Shanghai Jiaotong University School of Medicine, and colleagues assessed the predictive value of histopathologic classification in 186 patients with antineutrophil cytoplasmic antibodies-associated vasculitis (AAV). The classification — which consisted of focal, mixed, sclerotic and crescentic class — relied on the percentage of globally sclerotic glomeruli in renal specimens. In the meta-analysis, researchers included 1,601 patients.
Researchers found patients with focal class had the best renal outcome and patients with mixed class had the worst. In the meta-analysis, patients with focal class had better renal outcome than those with crescentic class (risk ratio = 0.23), who had better outcome than those with sclerotic class (risk ratio = 0.52), both without any evidence of heterogeneity. However, there was no significant association between mixed and crescentic class, also without any evidence of heterogeneity. The most common extrarenal manifestations were lung and upper respiratory tract involvement. – by Will Offit
Disclosure: The researchers report no relevant financial disclosures.
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