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Estrogen receptor polymorphism linked to OA in European patients
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The estrogen receptor ER-alpha Xbal polymorphism was weakly associated with osteoarthritis in Europeans, but not Asians, according to the results of a recently published analysis.
Researchers identified 11 studies of patients with osteoarthritis (OA) that focused on the association between ER-alpha polymorphisms and risk for OA. Eligible studies were cohort- or case-control-based, included patients who met the American College of Rheumatology criteria for OA and were focused on examining the relationship between OA and ER-alpha. In total, the research included 10 European and seven Asian groups comprising 5,325 patients with OA and 10,834 healthy individuals.
Statistical analysis of G and A alleles of ER-alpha Xbal showed the A allele was seen more frequently in patients with OA, and the AG genotype was less frequently seen. No apparent differences were seen between the GG genotype and patients with OA, according to the researchers.
Analysis of C and T alleles in the ER-alpha PvuII polymorphism showed a higher frequency of T alleles in patients with OA.
Once adjusted for ethnicity, no significant association was seen between the ER-alpha PvuII alleles in any population, but ER-alpha Xbal AA and GG genotypes were associated with OA in European patients, according to the researchers. – by Shirley Pulawski
Disclosure: The researchers report no relevant financial disclosures.
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