Schizophrenia News

A health economic study evaluating the financial impact of the GeneSight combinatorial pharmacogenomic test on major commercial health plans found that use of the test yielded reduced spending for a commercial health plan among patients with psychiatric disorders.

Findings from a multimodal, multisite machine learning analysis revealed that prediction models determined 1-year social-functioning outcomes in up to 83% of patients at clinical high-risk for psychosis and 70% of patients with recent-onset depression.

The FDA has accepted Allergan’s supplemental New Drug Application for Vraylar seeking to expand the indication to include the treatment of depressive episodes associated with bipolar I disorder in adults, according to a press release.

Study findings published in The Lancet Psychiatry showed that the cortical dopaminergic and glutamatergic systems appear related in patients with first-episode psychosis.

Data from three cross-sectional studies revealed that the latent structure of negative symptoms in schizophrenia was best conceptualized using a five-factor model with separate factors for the five consensus domains issued by NIMH — blunted affect, alogia, anhedonia, avolition and asociality.

Findings from a systematic review revealed a significant association between early childhood social adversity — including insecure attachment and adversity relating to neglect or abuse — and poorer social cognitive performance in participants with major psychiatric disorders.

Results from a large-scale genetic study showed that some of the same genes linked to cannabis use were also linked to certain psychiatric conditions and personality types.

Study findings showed that a single oral dose of cannabidiol modulated activation in parahippocampal, striatal and midbrain function, which are regions critical to the pathophysiology of psychosis.

Study results published in the American Journal of Psychiatry indicated that quetiapine exposure during first-trimester pregnancy was not strongly associated with major malformation in infants.

Children and teenagers with more frequent disruption in their residential environments were at higher risk for nonaffective psychosis, according to findings published in JAMA Psychiatry.