Schizophrenia News

Schizophrenia polygenic risk was significantly linked to insulin resistance in first-episode, antipsychotic-naive patients with schizophrenia regardless of demographic, lifestyle and clinical factors, according to a research letter published in JAMA Psychiatry.

Researchers have identified 413 genetic associations with schizophrenia across 13 brain regions by using a novel machine learning approach, according to a study published in Nature Genetics.

Adding IV sodium nitroprusside did not improve psychotic symptoms or cognition in antipsychotic-treated patients with schizophrenia who had a history of treatment resistance, according to a randomized clinical trial.

Exposure to air pollution was associated with psychotic experiences during adolescence, according to findings from a cohort study of children born in the U.K.

Data from a large study of national health care claims databases revealed that new-onset psychosis occurred in about one in 660 patients aged 13 to 25 years receiving prescription stimulants; however, the risk for psychosis was greater among those prescribed amphetamine than those prescribed methylphenidate.

Daily use of cannabis was associated with an increased risk for psychosis, study finding published in The Lancet Psychiatry revealed.

Treatment with olanzapine plus samidorphan, an opioid antagonist, resulted in 37% lower weight gain than treatment with olanzapine plus placebo in patients with schizophrenia, according to data from a phase 2 study.

Study findings revealed that neuromelanin-sensitive MRI may be a marker of dopamine function and an indicator of psychotic symptom severity in people with schizophrenia.

Although not all types of polypharmacy will lead to fewer rehospitalizations than monotherapies, study findings showed that combining aripiprazole with clozapine was associated with the lowest risk for rehospitalization in patients with schizophrenia in Finland.

Study findings indicated that adjunctive antidepressants were linked to a lower risk for psychiatric hospitalization and ED visits compared with alternative psychotropic medication strategies in patients with schizophrenia already taking an antipsychotic.