Mood Disorders News

Using machine learning, researchers from the University of Pennsylvania found that four dimensions of psychopathology — mood, psychosis, fear and disruptive externalizing behavior — were linked to distinct patterns of connectivity in the brain.

Researchers observed no long-term adverse effects in a small sample of patients with severe and treatment-resistant mood disorders who received ketamine infusions as clinical treatment.

Results from a meta-analysis of both region-of-interest and MRI studies in PTSD revealed specific brain abnormalities connected to the experience of trauma and PTSD diagnosis.

Results from a systematic review published in Journal of Clinical Psychiatry revealed a link between recent cannabis use and negative long-term symptoms and treatment outcomes among people with anxiety and mood disorders.

An integrative review published in Birth revealed that anger coexists with postpartum mood disturbances in women.

Older age was associated with poorer major depressive disorder course, according to 2-year follow-up data published in The Lancet Psychiatry.

Results from a systematic review and meta-analysis suggest that patients with current psychotic depression were at much higher risk for future psychotic depressive episodes than those with currently nonpsychotic MDD.

Adjunctive treatment with intranasal esketamine demonstrated long-term safety and delayed time to relapse in patients with treatment-resistant depression, according to results from two long-term phase 3 clinical studies presented at the American Society of Clinical Psychopharmacology annual meeting.

ALKS 5461, an investigational opioid system modulator that combines buprenorphine and samidorphan, showed antidepressant effects for up to 52 weeks of treatment in patients with major depressive disorder, according to data presented at the 2018 American Society of Clinical Psychopharmacology annual meeting.

Study results published in BMJ demonstrated long-term use of antidepressant medications was associated with an increased risk for weight gain over at least 5 years.