Alzheimer’s Disease/Dementia News

Multimodal neuroimaging showed varying relationships between indices of obesity and the brain at three different diagnostic stages, including cognitively healthy, mild cognitive impairment and Alzheimer’s disease dementia.

Patients with dementia, particularly patients with vascular dementia, experienced an increased risk for COVID-19, according to findings published in Alzheimer’s Disease & Dementia.

Severe cerebral small vessel disease, a common cause of vascular dementia, may be linked to apathy, fatigue and delirium, according to results of a systematic review and meta-analysis published in Lancet Psychiatry.

Severe perivascular space pathology served as a marker of increased risk for cognitive decline and dementia regardless of other markers of small vessel disease, according to findings from a prospective cohort study published in Neurology.

Donanemab, an investigational antibody that targets a modified form of beta amyloid, significantly slowed decline on a composite measure of cognition and daily function in early Alzheimer's disease, according to a press release.

The common frontotemporal dementia gene variations have different behavioral and neuropsychiatric disturbances and different trajectories through the course of the disease, according to study results published in JAMA Network Open.

Carriers of a variant for autosomal dominant Alzheimer’s disease and family members who did not carry the variant both experienced awareness of memory decline, but awareness of memory function decreased in carriers in predementia stages.

Masitinib, an oral tyrosine kinase inhibitor, improved measures of cognition, memory and activities of daily living in a phase 2b/3 study of patients with mild and moderate Alzheimer’s disease, according to a press release.

BP control may be critical for the preservation of cognitive function, according to a study published in Hypertension.

Greater amounts of air particulate matter correlated with the development of brain amyloid-beta plaques among older adults with cognitive impairment from over 5,000 U.S. Census tracts, according to a secondary analysis of the IDEAS study.