Top in endocrinology: Benefits of physical activity, harms of thyroid cancer overdiagnosis

A study found that any amount of physical activity protects against fractures in middle age people. It was the top story in endocrinology last week.

Another top story focused on overdiagnosis of thyroid cancer in children. Overdiagnosis could be a “major driver” of increased thyroid cancer incidence, a WHO scientist told Healio.

Read these and more top stories in endocrinology below:

Moderate physical activity may prevent fractures for middle-aged adults

Even moderate levels of leisure-time physical activity in middle age are associated with lower risk for fractures, according to study data published in the Journal of Bone and Mineral Research. Read more.

‘Overdiagnosis’ driving increased thyroid cancer incidence in children

Thyroid cancer incidence and mortality patterns among children and adolescents worldwide mirror data for adults, suggesting overdiagnosis and a need to “explicitly recommend” against screening for the disease in asymptomatic children. Read more.

Better trials needed to assess combination therapy for hypothyroidism

Three large professional thyroid organizations issued a joint statement calling for new trials of combination therapy to treat hypothyroidism, citing new clinical endpoints and the importance of assessing patient-reported outcomes. Read more.

Prescribe SGLT2 inhibitors, GLP-1 receptor agonists ‘as early as possible’ for CV benefit

Adults with type 2 diabetes assigned an SGLT2 inhibitor or a GLP-1 receptor agonist during cardiovascular outcomes trials derived benefit from the therapies regardless of whether they were prescribed insulin, according to a meta-analysis. Read more.

Inhaled insulin reduces HbA1c, body weight in 24-week trial

Among adults with type 2 diabetes, inhaled insulin was associated with HbA1c reductions similar to those with insulin aspart, fewer hypoglycemic episodes and lower body weight, according to a study published in Endocrine Practice. Read more.