Top stories from endocrinology: canagliflozin superior to dapagliflozin in real-word setting, insulin price gouge addressed

Among the top stories in endocrinology is that canagliflozin was superior to dapagliflozin in significantly reducing HbA1c levels. Stakeholders from the diabetes community addressed Congress and outlined the problems that contribute to the continuing increase of the price of insulin, severely limiting access for some patients. Other stories include most transgender and gender-nonconforming teens choosing to begin hormone therapy before preserving fertility, younger children appearing to have worse outcomes when it comes to the burden and treatment of differentiated thyroid carcinoma, and radiofrequency ablation emerging as potentially a more viable option of treatment among adults with symptomatic benign thyroid nodules.

Real-world efficacy differs among SGLT2 inhibitors

Adults with type 2 diabetes more often reached their glycemic goal and had greater reductions in HbA1c level when they were prescribed canagliflozin vs. dapagliflozin, according to an analysis of claims data for the SGLT2 inhibitors. Read More.

Senators, diabetes stakeholders seek transparency in insulin pricing

Stakeholders from the diabetes community brought their growing concerns regarding rising insulin prices before Congress on Tuesday, outlining the complex problems that place a lifesaving drug almost out of reach for some people with diabetes and seeking help from legislators to demand more accountability in drug pricing. Read More.

Few transgender teens opt to delay HT to preserve fertility

Most transgender and gender-nonconforming adolescents do not consider fertility preservation an important reason to delay the start of hormone therapy, but some cite parental attitudes regarding biological offspring as influencing any decision regarding treatment, according to survey data presented at the Pediatric Academic Societies Meeting. Read More.

Poorer differentiated thyroid cancer outcomes seen in younger children vs. teens

The early disease burden and treatment of differentiated thyroid carcinoma is similar in younger children and adolescents, but younger children appear to have worse outcomes, even without nodal metastases, and this may necessitate therapy intensification or tumor monitoring, according to recent findings. Read More.

Radiofrequency ablation viable option for symptomatic benign thyroid nodules

Adults with symptomatic benign thyroid nodules who underwent a single, monopolar radiofrequency ablation treatment in lieu of surgery experienced significant overall nodule volume reduction at 12 months with mostly minor, transient complications, according to findings from a single-center study conducted in Austria. Read More.