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DTwP decreased risk for pertussis in teenagers more than DTaP
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Teenagers had a decreased risk for pertussis if they were vaccinated with diphtheria, tetanus toxoids and whole-cell pertussis vaccines as children compared with those vaccinated with combined acellular pertussis vaccines, according to recent study results published in Pediatrics.
“Teenagers who were vaccinated with four doses of [diphtheria, tetanus toxoids and acellular pertussis] vaccines were at almost six times higher risk of pertussis than were those who had received four doses of [diphtheria, tetanus toxoids and whole-cell pertussis] vaccines,” researchers wrote.
Nicola Klein
The case-control study included children born from 1994 to 1999 who received four pertussis–containing vaccines at Kaiser Permanente Northern California (KPNC) during the first 2 years of life. Pertussis PCR-positive cases (n=138) were compared with 899 PCR-negative and 54,399 KPNC-matched controls.
Researchers found that participants who received four diphtheria, tetanus toxoids and whole-cell pertussis (DTwP) vaccines were less likely to be PCR-positive than those who received four DTaP vaccines (OR=5.63; 95% CI, 2.55-12.46) or mixed DTwP/DTaP vaccines (OR=3.77; 95% CI, 1.57-9.07). They also found that there was a 40% average increased risk for pertussis for each additional DTaP dose received instead of DTwP.
“Protection from pertussis appeared to be dose related, as persons who received mixed DTwP and DTaP vaccines had an intermediate level of risk between those who received all DTwP or all DTaP vaccines; those who received mixed vaccines were at nearly four times higher risk of pertussis than were those who received all DTwP vaccines,” researchers wrote.
Disclosure: The study was funded by Kaiser Permanente. Two researchers report financial ties with GlaxoSmithKline, MedImmune, Merck & Co., Novartis, Pfizer and Sanofi-Pasteur.
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