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Amoxicillin may pose less rash risk in those with acute infectious mononucleosis
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Children who have acute infectious mononucleosis and are treated with amoxicillin may not be at higher risk for rash compared with other antibiotics, according to data published online.
Amir Ben Tov, MD, of the Dana-Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center, and colleagues looked retrospectively at 173 hospitalized children in two pediatric tertiary medical centers in Israel. The researchers reviewed data on children who had been diagnosed with acute infectious mononucleosis and treated with antibiotics vs. patients who had been treated with other therapy.
“Amoxicillin was associated with the highest incidence of antibiotic-induced rash occurrence, but significantly lower than the 90% rate reported for ampicillin in past studies,” the researchers wrote. “Previous cohort studies of antibiotic-induced rash in patients with [acute infectious mononucleosis] investigated ampicillin, with little attention having been given to amoxicillin. An association of the development of a rash with the use of amoxicillin has been mentioned in only a few case reports.”
The researchers offered that absorption and urinary excretion “rates of amoxicillin have been shown to be better than ampicillin,” which may have played a role.
Amir Ben Tov, MD, can be reached at amir.bentov@gmail.com.
Disclosure: Ben Tov reports no relevant financial disclosures.
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