Biologics News

Topical and systemic vitamin A analogues do not alter fracture risk, according to a Danish database study in which patients with fractures were matched to three demographically similar patients without fractures.

With much osteoporosis research focusing on vertebral fractures and trabecular bone loss, a team of Australian researchers recently theorized from their cross-sectional study of women’s bones that medications targeting age-related cortical bone loss occurring after age 65 years may ultimately improve the treatment and diagnosis of osteoporosis.

HOLLYWOOD, Fla. – Concentrated bone marrow aspirate with one-step implantation of mesenchymal stem cells can be a viable alternative in the treatment of grade IV chondral lesions of the knee, according to a study presented here.

The U.S. Food and Drug Administration warned health care professionals and patients that an increased risk of hip, spine and wrist fractures has been associated with high doses or chronic use of proton pump inhibitors, medicines commonly used to reduce stomach acid.

A large consecutive case series of multilevel fusions treated with recombinant human bone morphogenetic-2 yielded a 10.2% pseudarthrosis rate at 6 months.

A discovery by investigators at Stanford University could lead to the development of new drugs that provide the same benefits to the skeleton as exercise and could be used to treat patients with osteoporosis.

Biologic joint reconstruction, rather than bionic replacement, may be an appropriate first step for many people with knee joint arthritis, according to recently presented research results.

Several limitations associated with traditional grafting materials may be overcome by using a high-performance shape memory polymer based on rigid nanoparticle cores and developed by researchers at University of Massachusetts Medical School.

Researchers have developed a biocompatible and biodegradable screw used for the stabilization of ligament ruptures that will not require patients to undergo further surgery for screw removal, according to a Fraunhofer-Gesellschaft press release.

Preclinical and clinical studies using stem cells to enhance spine fusion and treat disc degeneration are underway in the United States and internationally. Cells used in these cell therapy techniques can come from various sources, however each type of cell and its properties have pros and cons for spine and other clinical applications.