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Biologics News
Lieberman receives NIH grant for research on gene therapy for repair of bone injuries
Jay R. Lieberman, MD, chair and professor of orthopedic surgery at Keck School of Medicine of the University of Southern California received a 5-year, $2.2 million grant from the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases for gene therapy research to enhance repair of extensive bone injuries, according to a press release.
Greater number of mesenchymal stem cells released with fibrous synovium in culture model
Investigators of this study found fibrous synovium compared with adipose synovium release a greater number of mesenchymal stem cells in a suspended synovium culture model.
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Etanercept seen as effective against bone marrow lesions in patients with hand OA
LAS VEGAS — Etanercept was effective for the inhibition of bone marrow lesions in patients with erosive hand osteoarthritis, according to a presenter here at the Osteoarthritis Research Society International World Congress.
Etanercept linked with pain relief in prespecified per-protocol analysis of symptomatic hand OA
LAS VEGAS — Although investigators found non-superiority of etanercept compared with placebo overall in their study, they noted an analysis of patients with symptomatic and inflammatory hand osteoarthritis treated with etanercept had superior pain scores.
Adalimumab did not provide significant relief of pain, synovitis in patients with hand OA
LAS VEGAS — Patients with erosive hand osteoarthritis treated with adalimumab experienced no significant alleviation of pain, synovitis or bone marrow lesions compared with patients treated with placebo, according to results presented here.
DePuy Synthes acquires 3-D printing technologies from Tissue Regeneration Systems
DePuy Synthes Products Inc. has acquired 3-D printing technology from Tissue Regeneration Systems Inc.
Athletes with shoulder instability had significantly lower levels of specific collagen biomarker
Athletes with shoulder instability had significantly lower levels of the cartilage degradation marker collagen type II cleavage compared to athletes without shoulder instability, according to results.
EFORT Open Reviews: A round-up of recently published articles
EFORT Open Reviews is the new open access journal from EFORT and The British Editorial Society of Bone & Joint Surgery. All articles are free to read online with no subscription required.
Bone marrow aspirate concentrate, saline placebo had similar pain relief for knee OA
Bone marrow aspirate concentrate was seen as a safe, reliable and viable cellular product for patients with bilateral knee pain from bilateral osteoarthritis, according to results.
HA-BMAC yielded more durable knee cartilage repair at 5 years vs microfracture
A hyaluronic acid-based scaffold with bone marrow aspirate concentrate used in patients with a chondral injury achieved better outcomes and more durable cartilage repair at medium-term follow-up than microfracture.
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